SINCE Straumfjord1 reported that the daily administration of 100,000 I. U. of vitamin A for periods of nine to 18 mo. resulted in the disappearance or the improvement of the lesions in all but three of 100 cases of acne vulgaris, vitamin A has occupied a prominent place in the treatment of that disease. Saunders2 found that 100,000 units of vitamin A taken daily for chronic sinusitis cleared the acne vulgaris on his back in six months. Recurrence was noted after four months when vitamin A was stopped. The vitamin therapy was started again, and in three months the back was clear once more. Obermayer and Frost3 were less enthusiastic but stated that
vitamin A therapy is undoubtedly of benefit in the handling of some forms of acne vulgaris while others do not seem influenced by it. It seems that acne which is characterized by prominent follicular
MITCHELL GH, BUTTERWORTH T. RESULTS OF TREATMENT OF ACNE VULGARIS BY INTRAMUSCULAR INJECTIONS OF VITAMIN A. AMA Arch Derm Syphilol. 1951;64(4):428–430. doi:10.1001/archderm.1951.01570100045006
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