IN JUNE, 1947, chloramphenicol1 was first given to a patient with chronic discoid lupus erythematosus. All of the other currently advocated drugs (gold sodium thiosulfate, bismuth by mouth and by intramuscular injection, and paraaminobenzoic acid) had given such uniformly poor results that this antibiotic drug was tried in the hope that it might prove of greater value than the others.
The improvement in the lesions in the first patient treated was so noticeable and rapid (within one week) that it was decided to continue the treatment for this patient, and 12 more patients with the same disease were added, making a group of 13 under treatment. Patients were given 1 or 1.25 gm. of chloramphenicol divided into four or five doses of 250 mg. each.
The results at that time seemed of sufficient academic interest to warrant a preliminary report.2 All of these patients have now been followed