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November 1951


AMA Arch Derm Syphilol. 1951;64(5):645-648. doi:10.1001/archderm.1951.01570110115023

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Treatment of Chloasma with Monobenzyl Ether of Hydroquinone. Presented by Dr. Alexander A. Fisher.  M. F., a woman aged 32, has had a variety of treatment for chloasma, which included solid carbon dioxide, hydrogen peroxide, alcoholic solution of mercury bichloride, strong alkaline soaps, and salicylic acid in alcohol.On June 2, 1949 she began using 2% monobenzyl ether of hydroquinone in "laviderm." Fifteen days later an allergic contact-type eczematous eruption appeared in the areas where the ointment was rubbed in.Reaction to patch tests with the above ointment and a 2% aqueous solution of monobenzyl ether of hydroquinone were strongly positive. Reaction to a patch test with "laviderm" was negative.There was no apparent improvement in the chloasma after the contact dermatitis cleared.

DISCUSSION  Dr. Marion B. Sulzberger: Many years ago, when the first reports came out on loss of pigment from Age Rite Alba in rubber gloves, Dr. Ludwig

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