THERE is general agreement today that the treatment of lupus vulgaris by massive dosage with vitamin D2, as first described by Charpy (1943 and 1946)1 and by Dowling and Prosser Thomas (1945 and 1946),2 leads to marked clinical improvement in most cases and apparent cure in some. Ruiter and Groen (1950)3 reported clinical cure in 32% of 100 patients and stated that the clinical cures reported by other authors vary from 24 to 60%. Ingram and Anning (1948),4 on the other hand, reported cure in about 2.5% of 158 patients treated, whereas Gauvain (1948)5 reported clinical cure in 8 of 11 patients treated (72%). These widely differing percentage results may depend on variable criteria of cure employed by different authors and on varying dosages and techniques.
Nevertheless, Ruiter and Groen reported that 9% of their patients were refractory to this treatment and another
RUSSELL B. TREATMENT OF LUPUS VULGARIS BY INTRALESIONAL INJECTIONS OF CALCIFEROL: Its Use in Localized, Recurrent, or Refractory Cases. AMA Arch Derm Syphilol. 1951;64(6):676–683. doi:10.1001/archderm.1951.01570120011002
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