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Article
December 1951

CLINICAL EVALUATION OF "DIPHENYLPYRALINE" AS AN ANTIFUNGAL AGENT

AMA Arch Derm Syphilol. 1951;64(6):754-756. doi:10.1001/archderm.1951.01570120089008
Abstract

CARSON and Campbell1 reported that ``diphenylpyraline'' (1-methyl-piperidyl-4 benzhydryl ether) had marked in vitro antifungal action against a group of organisms, including Trichophyton rubrum, Microsporum gypseum, Microsporum lanosum, Epidermophyton floccosum, and Candida albicans. These authors enthusiastically suggested that clinical corroboration should be attempted. In response to this suggestion, a therapeutic trial was carried out.

Except for the use of microscopic and culture technics, such as the use of a standard Sabouraud agar culture medium, to check clinical diagnosis, the study was entirely clinical. The chemical, pharmacologic, and physiologic aspects of ``diphenylpyraline'' will not be discussed at this time. Studies of these aspects have been accomplished elsewhere, and the results are to be published.

The mode of administration of ``diphenylpyraline''2 was limited to topical application. The active agent was incorporated in two separate vehicles, the selection of which was guided by the physical state of the eruption. In wet, oozing,

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