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February 1952


AMA Arch Derm Syphilol. 1952;65(2):233. doi:10.1001/archderm.1952.01530210112017

Sulfoxone sodium (diasone®) has been used by Cornbleet1 since 1944 in the treatment of dermatitis herpetiformis. He has indicated that he has obtained good results. A much less toxic sulfone, also used in the treatment of leprosy, has been under study in the Department of Dermatology at the University of Cincinnati College of Medicine since 1949. This preparation is an acetosulfone (promacetin®) (sodium 4,4′-diaminodiphenylsulfone-2-acetylsulfonamide) for the treatment of sarcoidosis. The toxic reactions seen during this period of study have included only occasional nausea, one probable drug-allergy reaction of pharyngitis, and one drug fever. No serious blood or renal disturbances have been seen, even on prolonged courses. It appears, then, that promacetin® may be used when treatment must be continued for some time.

After Cornbleet's report, promacetin® was used in the treatment of nine patients with dermatitis herpetiformis with an average initial dose each