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April 1952


AMA Arch Derm Syphilol. 1952;65(4):451-457. doi:10.1001/archderm.1952.01530230075007

AMYLOID deposits are found in the skin in many diverse and unrelated conditions. The skin is rarely involved in the secondary systemic amyloidosis following chronic wasting diseases, but more often accompanies primary systemic amyloidosis with macroglossia. These comparatively rare conditions apparently have no connection with each other nor with the common localized amyloidosis cutis with which we are concerned in this report.

First described as amyloidosis cutis nodularis et disseminata by Gutmann1 in 1928 and as lichen amyloidosis by Freudenthal2 in 1930, this disease has been the subject of many reports in this country and abroad. Several varieties have been reported. In all these cases the lichenoid character of the primary lesion has been emphasized. This primary lesion has been described by Andrews3 as a "small brownish, and slightly scaly papule which seems to be translucent and simulates a vesicle, but the fully developed papules are