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June 1952

TREATMENT OF PYODERMAS WITH PENICILLIN 92Comparison with Neomycin and Bacitracin

AMA Arch Derm Syphilol. 1952;65(6):656-662. doi:10.1001/archderm.1952.01530250020002

SOME TIME ago the director of the Hektoen Institute, which is the division of research of the Cook County Hospital in Chicago, enlisted our cooperation for a study of several new antibiotic agents. The Institute was interested particularly in a new type of penicillin, l-ephenamine penicillin G (penicillin 92).1 It has an antibacterial spectrum which in vitro parallels that of penicillin G, but which differs from it in one important respect. l-Ephenamine penicillin G is thought to have hypoallergenic properties similar to those attributed to penicillin O.2

Although there are many excellent agents available for the topical treatment of pyogenic infections of the skin, each of them has certain limitations. The better ones are the broad-spectrum antibiotics, but even among these there is none that has proved to be effective in all cases. All the antibacterial drugs on occasion may produce allergic reactions, while some

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