RECENT years have witnessed the advent of a number of new agents for local therapy in pyogenic infections of the skin. Certain of these, however, are not without disadvantages. Topical use of the sulfonamides and penicillin, while very effective, has resulted in sensitization in at least 5 and 10% of the cases, respectively,1 with indications that reactions to penicillin are increasing both in frequency and in severity. The use of nitrofurazone (furacin®) has likewise resulted in a significant degree of sensitization, reactions occurring in about 5% of the cases.2 Good results have been reported3 for dihydrostreptomycin in topical therapy, with sensitization manifested in 3.7% of patients treated. Prolonged use of this drug was not recommended, however, because of the rapid development of drug-fastness. The incidences of reactions obtained with the sulfonamides, penicillin, and dihydrostreptomycin thus become of importance, especially since these drugs are intended
GASTINEAU FM, FLORESTANO HJ. CLINICAL EXPERIENCE WITH ``POLYCIN,'' A POLYMYXIN-BACITRACIN OINTMENT. AMA Arch Derm Syphilol. 1952;66(1):70–75. doi:10.1001/archderm.1952.01530260073007
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