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Article
September 1952

INFLAMMATORY NODOSE LESIONS OF THE LOWER LEG

AMA Arch Derm Syphilol. 1952;66(3):327-332. doi:10.1001/archderm.1952.01530280031004
Abstract

NODOSE lesions of the lower leg are usually classified according to their characteristics; thus, we speak of three principal varities: (1) erythema nodosum, (2) erythema induratum, and (3) nodular vasculitis. Erythema nodosum was for many years considered to be an acute cutaneous disease, closely allied to erythema multiforme, and because it responded to salicylates, it was thought that it might be a rheumatoid disease. Erythema induratum is a term reserved to describe those indurative lesions which occur almost exclusively on the lower leg in cases of tuberculosis and which are known to be tuberculous in origin. Nodular vasculitis is a term that has been applied to a number of nodular conditions, the causation of which cannot be ascertained, but the morphology of which reveals the group to be closely aligned anatomically to the other two types. It is a widely inclusive term, embracing both acute and chronic

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