IT HAS been shown by Miescher and Schönberg1 that the ratio of sebaceous gland secretion to sebaceous gland area in a given area of the skin is constant. In other words, the amount of sebaceous gland secretion is dependent on the size and number of sebaceous glands only; any substance which increases (or decreases) the sebaceous gland secretion does so by increasing (or decreasing) the size of the sebaceous gland.
Basic evidence is accumulating to indicate that the androgens and the estrogens when given internally or applied topically influence the size of the sebaceous gland in laboratory animals as well as in human beings.
Androgens (for example, testosterone propionate) cause an increase in the size of the sebaceous gland, as was shown by the studies of Hamilton2 and Rony and Zakon3 with human subjects, and by Montagna and Kenyon4 and Hamilton and Montagna5 with laboratory
LOBITZ WC, COLE DP. DIETHYLSTILBESTROL IN THE TREATMENT OF SENILE SEBACEOUS ADENOMA. AMA Arch Derm Syphilol. 1952;66(3):358–362. doi:10.1001/archderm.1952.01530280062009
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