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Mrs. E. M. M. was admitted to the University Hospital May 11, 1951, with a progressive bullous eruption involving the left eyelid, trunk, arms, and legs, with marked lesions in the inguinal region. The case was studied in routine form from the clinical and laboratory stand point. A biopsy was done on May 22, 1951, and was reported as revealing acute pemphigus vulgaris. Figure 1 shows the patient on this date. Treatment was started with the use of the patient's own blood serum, prepared and given in the following manner: Thirty to 35 cc. of blood was drawn at weekly intervals under aseptic conditions; the blood was refrigerated overnight and centrifuged; the serum was drawn off and heated in a hot water bath at 56 C.