BLOOD dyscrasias, particularly the congenital hemolytic anemias,1 are of primary importance in a consideration of the possible causes of chronic recurrent ulcers of the leg. An association of leg ulcers with sickle cell anemia is generally better appreciated than the relationship of this symptom to other forms of congenital hemolytic anemia, e. g., congenital hemolytic icterus (familial acholuric jaundice, spherocytic anemia) and Mediterranean disease (Cooley's anemia, thalassemia).
In a review of the subject of indolent ulcers of the leg in diseases of the blood, in addition to the conditions already mentioned, Gendel2 lists the following: Banti's syndrome, thrombocytopenic purpura, Gaucher's disease, pernicious anemia, and chronic hemolytic polycythemia. The latter was presented before the Royal Society of Medicine by Rau, Pulvertaft and Humble.3 Gendel2 did not include polycythemia vera (erythremia, Osler-Vaquez disease). However, ulcerations of the lower extremities4 and peripheral vascular complications have
PASCHER F, KEEN R, Simm F. CHRONIC ULCERS OF THE LEG ASSOCIATED WITH BLOOD DYSCRASIAS. AMA Arch Derm Syphilol. 1952;66(4):478–487. doi:10.1001/archderm.1952.01530290054007
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