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October 1952

ERYTHEMA GYRATUM REPENS: Skin Manifestations in Patient with Carcinoma of Breast

Author Affiliations


From the Department of Dermatology and Syphilology of Western Reserve University and University Hospitals of Cleveland, service of Dr. H. N. Cole.

AMA Arch Derm Syphilol. 1952;66(4):494-505. doi:10.1001/archderm.1952.01530290070010

THE DERMATOLOGIST of the twentieth century has been trained to consider the possibility of internal diseases in all cases of atypical, bizarre, or recalcitrant dermatoses. As skin lesions are frequently the first signs of various types of malignant lymphoma, he is often in a position to suspect these fatal diseases before a clinical or laboratory diagnosis is possible. The association of acanthosis nigricans and visceral cancer is well known, as are metastases to the skin from internal cancers. Other skin eruptions have been observed in the presence of cancer and sarcoma, but they are rather rare. In some instances they may have been coincidental; in others a causal relationship is almost certain. In most cases the patients came first to the dermatologist, who later referred them to the surgeon or roentgenologist.


In 1925 Rothman1 wrote a comprehensive review on the subject of cutaneous manifestations in patients

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