ON TAKING stock after many years, psoriasis remains a riddle, and little more is known today than was known in 1913, when Schamberg first reported on it to this society. A postulation for conditions which might lead to a psoriatic eruption would appear to be (1) a potentially psoriatic person and (2) an endogenous or exogenous impulse that causes this potentiality to become manifest. This statement implies that psoriasis is not an entity, i. e., not dependent on one single cause. Psoriasis appears to be one of those skin eruptions which develop because a particular skin can respond to many different injuries with the same morphological reaction. A rule long disputed seems to be proved again. The same cause can produce quite different morphological reactions on the skin, and, quite different causes may produce the same morphological reaction on the skin.
This extraordinary, but nowadays generally accepted, fact
GANS O. SOME OBSERVATIONS ON THE PATHOGENESIS OF PSORIASIS. AMA Arch Derm Syphilol. 1952;66(5):598–611. doi:10.1001/archderm.1952.01530300054006
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