PODOPHYLLOTOXIN1 quercetin,2 α-peltatin,3 and β-peltatin4 are crystalline compounds in podophyllin. We contended previously5 that podophyllotoxin was the component responsible for involution of condyloma acuminatum. When α- and β-peltatin became available,6 32 patients were treated (Table 1). Satisfactory results necessitate including these substances as effective agents against moist genital warts. The clinical response to the topically applied peltatins was identical with that described in detail for podophyllin and podophyllotoxin7 except that the peltatins produced negligible irritation to circumjacent normal tissue. Microscopic examination of involuting warts at 24 and 48 hours showed changes7 identical with those