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December 1952

FURTHER AMPLIFICATION OF THE CONCEPT OF DERMATOPHYTID: I. Erythema Annulare Centrifugum as a Dermatophytid

Author Affiliations


AMA Arch Derm Syphilol. 1952;66(6):738-745. doi:10.1001/archderm.1952.01530310076011

Dermatophytid is the name given the group of skin diseases resulting from allergic reactions to fungous infection of the skin—so-called dermatophytosis. The following minimal criteria must be fulfilled in order to establish the diagnosis of dermatophytid:

  1. Focus of dermatophytosis

  2. Positive skin test to trichophytin

  3. Precipitation of dermatophytid due to blood-borne fungi or fungous products released by

    a. Activation of dermatophytosis

    b. Overtreatment of the dermatophytosis

  4. Absence of fungi in the dermatophytid lesions

  5. Clearing of dermatophytid after the dermatophytosis has been eradicated

Various investigators have proposed that the following are types of dermatophytids:

  1. Disseminated papular lesions1

  2. Vesicular lesions of the hands 2

  3. Erysipelas-like dermatitis of the lower extremities (may eventuate in chronic lymphedema) 3

  4. Migrating thrombophlebitis and thromboangiitis obliterans 4

  1. Urticaria (often associated with asthma and vasomotor rhinitis) 5

  2. Miscellaneous group (erythema multiforme, erythema nodosum, exfoliative dermatitis, lesions simulating pityriasis rosea, and erythema annulare centrifugum) 6

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