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December 1952

SULFOXONE (DIASONE®) SODIUM DERMATITISUnusual Distribution in a Patient with Leprosy

AMA Arch Derm Syphilol. 1952;66(6):748-749. doi:10.1001/archderm.1952.01530310086013

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When sulfoxone (diasone®) sodium has been used in the treatment of leprosy, several instances of dermatitis medicamentosa have occurred. Lesions resembling erythema nodosum are known to be produced by this sulfone. However, it is the distribution of the eruption which has been of primary interest to us, rather than the type and nature of the lesion. We have encountered patients with dermatitis medicamentosa from sulfoxone sodium in whom it has been difficult to determine whether the lesions were due to the underlying condition or were actual drug eruptions. This confusion arose in cases in which the distribution of the erythematous nodules due to sulfoxone sodium occurred in areas characteristically involved by leprosy. We are reporting a case of this type of dermatitis in a patient with the lepromatous type of leprosy.


R. H., a 52-year-old-man, was initially seen in July, 1951. He was born

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