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January 1953

PEMPHIGUS IN ASSOCIATION WITH PREGNANCY: Observations of the Effect of Corticotropin (ACTH) and Cortisone on the Pemphigus, the Pregnancy, and the Infant

AMA Arch Derm Syphilol. 1953;67(1):10-17. doi:10.1001/archderm.1953.01540010014002

THE REPORT of this case record of a patient with pemphigus in association with pregnancy presented several interesting facets. The following features will be discussed: (1) the occurrence of pemphigus in a relatively young person; (2) the rarity of this disease in association with pregnancy; (3) the effect of the pregnant state on pemphigus; (4) the clinical and laboratory results following treatment with corticotropin (ACTH) and cortisone; (5) evidence to demonstrate the lack of effect of cortical hormone therapy on the developing fetus; (6) evidence to demonstrate the lack of effect of the primary disease process on the fetus, and (7) the change of a picture from pemphigus vulgaris into pemphigus foliaceus during the course of hormone therapy.


In a statistical analysis of 170 cases reviewed by Gellis and Glass,1 pemphigus occurred in the 20 to 30 age group in 15 cases, an incidence