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Article
January 1953

TREATMENT OF PYOGENIC SKIN INFECTIONS WITH PENICILLIN GIVEN ORALLY

Author Affiliations

SAYRE, PA.

From the Department of Dermatology of Guthrie Clinic and Robert Packer Hospital.

AMA Arch Derm Syphilol. 1953;67(1):42-43. doi:10.1001/archderm.1953.01540010046006
Abstract

THE EFFECTIVENESS of the use of penicillin in a variety of infections has been established by Keefer,1 Bunn and his associates,2 and others. Flippin and Israel3 demonstrated that effective plasma levels can be produced with 200,000-unit tablets taken three or four times daily.

The purpose of this report is to show the effectiveness of orally administered penicillin in the treatment of pyogenic dermatoses. The subjects for treatment were selected on the basis of their having a clinically demonstrated pyogenic infection, and bacterial cultures were obtained before treatment in all cases except one. No other treatment, such as wet dressings or local applications of ointments, was used.

The Table presents the cases and the results obtained. In all cases except one the response was immediate and the pyogenic infection was well under control in three to four days. Therapy was continued usually in reduced dosage, beyond

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