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Article
February 1953

LOCAL TISSUE REACTIONS TO CORTISONE AND HYDROCORTISONE (COMPOUND F) IN MAN

Author Affiliations

CINCINNATI

From the Department of Dermatology and Syphilology of the College of Medicine of the University of Cincinnati.

AMA Arch Derm Syphilol. 1953;67(2):163-165. doi:10.1001/archderm.1953.01540020041008
Abstract

WE HAVE reported previously our investigative studies concerning the detection of compound F crystals injected into the skin; the histopathology of the reactions of normal and pathologic skin to compound F; some investigative studies on the eczematous, tuberculin, and arthropod bite reactions in the skin, and the oral use of compound F in skin diseases.1 We should like to report in this paper the results of a study of the local therapeutic effect of compound F in 460 patients observed during the past two years.

Compound F was given by needle and syringe, by the hypospray® jet injection apparatus, in various ointment vehicles, and as a suspension in various solutions. In 160 patients, compound F acetate and the free alcohol of compound F were given orally. These patients will not be included in this report.

The results with the ointments in 135 patients given compound F acetate

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