WE HAVE reported previously our investigative studies concerning the detection of compound F crystals injected into the skin; the histopathology of the reactions of normal and pathologic skin to compound F; some investigative studies on the eczematous, tuberculin, and arthropod bite reactions in the skin, and the oral use of compound F in skin diseases.1 We should like to report in this paper the results of a study of the local therapeutic effect of compound F in 460 patients observed during the past two years.
Compound F was given by needle and syringe, by the hypospray® jet injection apparatus, in various ointment vehicles, and as a suspension in various solutions. In 160 patients, compound F acetate and the free alcohol of compound F were given orally. These patients will not be included in this report.
The results with the ointments in 135 patients given compound F acetate
GOLDMAN L, PRESTON RH. LOCAL TISSUE REACTIONS TO CORTISONE AND HYDROCORTISONE (COMPOUND F) IN MAN. AMA Arch Derm Syphilol. 1953;67(2):163–165. doi:10.1001/archderm.1953.01540020041008
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