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Article
April 1953

LUPUS VULGARIS TREATED WITH ISONIAZID: A Preliminary Report

Author Affiliations

INDIANAPOLIS

From the Department of Dermato-Syphilology and the Alembert Winthrop Brayton Skin and Cancer Foundation of the General Hospital, Dr. John Eric Dalton, chairman.

AMA Arch Derm Syphilol. 1953;67(4):413-418. doi:10.1001/archderm.1953.01540040071011
Abstract

The benefits reported from isoniazid (isonicotinic acid hydrazide) therapy in other tuberculous diseases1 led to its employment in a resistant case of lupus vulgaris.

REPORT OF A CASE

A 34-year-old Negro woman (W. M.) has been seen intermittently since 1926, because of a persistent, extending patch of lupus vulgaris of the left cheek. Other personal and family history has been unrevealing.

At onset, there was a small, chronic, superficial erosion of the left malar area. By 1931, the lesion was 3 by 1 in. (7.6 by 2.5 cm.), triangular, centrally eroded, crusted, and indurated. By 1946, it showed a verrucous surface, edema, a depigmented central cicatrix, and discrete erythematous peripheral papules which were apple-jelly-colored under diascopic pressure. The process continued active.

The von Pirquet and Mantoux (1:100,000) tests were positive. Repeated sputum examinations, urinalyses, blood serologic tests, complete blood counts, albumin-globulin ratios, and x-ray plates of the

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