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Article
April 1953

NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILIS: Annual Residents' Meeting

AMA Arch Derm Syphilol. 1953;67(4):424-430. doi:10.1001/archderm.1953.01540040082013

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Abstract

Reticuloendotheliosis (Letterer-Siwe Disease). Presented by Dr. Ralph Teicher.

J. P., an Italian girl aged 16 months, is presented from the Vanderbilt Clinic with anemia and a generalized cutaneous eruption, of one year's duration. She was well except for feeding problems until the age of 5 months, when tonsillitis and a temperature of 103 F. developed. She was given a sulfonamide drug, with the prompt development of a generalized hemorrhagic, vesicular eruption, including the palms and soles. Use of the drug was stopped, with gradual subsidence of the eruption during the next two weeks. At 7 months of age a scaling eruption of the scalp, eyebrows, and ears developed and persisted despite local therapy. Recurrent attacks of otitis, tonsillitis, and febrile convulsions led to the discovery of a severe anemia and an enlarged spleen. The patient was admitted to Babies' Hospital for study.

The scalp shows a scaling, erythematous eruption

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