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June 1953

BACILLUS ANTHRACIS: Observations on In Vitro Sensitivity to Seven Antibiotics with a Comment on Therapeutic Implications

Author Affiliations


AMA Arch Derm Syphilol. 1953;67(6):541-545. doi:10.1001/archderm.1953.01540060003001

ANTHRAX, while not a rare disease, is an uncommon one, and only an occasional investigator has the opportunity of receiving within a short span of time a significant number of strains of Bacillus anthracis freshly isolated from human cases of anthrax. This, plus the fact that there is a general reluctance to handle the organism, based on the difficulty of destroying anthrax spores which have once contaminated a room, seemed to justify the reporting of the present study.

Because of unique circumstances, 29 strains of B. anthracis isolated from patients suffering from cutaneous anthrax became available to us. Fifteen of the strains had been preserved at 20 C. for periods ranging from 10 to 13 years after their isolation from human infections.1 The virulence of these strains was established by guinea pig tests, with deaths occurring in 100% of the animals within 96 hours and in the majority of