[Skip to Content]
[Skip to Content Landing]
June 1953

ERYTHEMA ANNULARE CENTRIFUGUM Its Relation to Internal Disease

AMA Arch Derm Syphilol. 1953;67(6):590-593. doi:10.1001/archderm.1953.01540060052007

ERYTHEMA annulare centrifugum, a rare dermatosis, usually occurs in otherwise healthy persons: however, some cases have been reported in which it was associated with internal disease. Because of the possibility of discovering a clue to its etiology, such cases are of especial interest. I wish to record one that I observed for a short time.


Mrs. J. S., a 60-year-old white housewife, a native of the United States, had a total hysterectomy and salpingectomy in 1941. The uterus contained fibroids and a hypertrophic endometrium; there were subserous cysts of the Fallopian tubes, and an ovarian fibroid. No sign of carcinoma was found.

Late in 1950 the patient began to suffer from painful swellings of the legs, malaise, and anorexia, with diffuse aching pains followed by swelling of the abdomen. A series of deep x-ray treatments relieved her; the abdominal swelling and edema of