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Article
August 1953

CAPILLARY MICROSCOPIC EXAMINATION IN SKIN DISEASES

Author Affiliations

ROCHESTER, MINN.

From the Section of Dermatology (Dr. O'Leary) and the Section of Biophysics (Dr. Baldes), Mayo Clinic.

AMA Arch Derm Syphilol. 1953;68(2):136-147. doi:10.1001/archderm.1953.01540080020003
Abstract

SOME FEATURES of a dermatosis may be recognized by direct observation of the skin, and a magnifying glass may help in seeing more of the detail. Epidermoscopy1 and diascopy2 may give additional help in the study of certain skin lesions. Coloroscopy is a new technique for studying microscopic organisms and human tissues with colored polarized light. Since these methods of inspection permit of superficial study only, microscopic examination is still the best procedure to determine the pathologic changes in the skin. It is, however, a study of dead tissue and has its limitations, according to histopathologists.3

A direct study of the pathologic and physiologic changes in the living skin under natural conditions may be done by means of capillary microscopy. This is a method of observing the superficial cutaneous vessels through a microscope under direct incident illumination after the skin has been made transparent by

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