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August 1953


AMA Arch Derm Syphilol. 1953;68(2):225-228. doi:10.1001/archderm.1953.01540080109017

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Leprosy (Lepromatous Type) Improved by Isoniazid (Nydrazid; Isonicotinic Acid Hydrazid). Presented by Dr. Maurice J. Costello.

R. R., a Puerto Rican woman aged 25, was seen by Dr. Walter Gassner complaining that she burned her hands and forearms frequently. Examination at that time revealed third-degree burns of the hands and forearms, a nodular eruption of the extremities, loss of the outer third of the eyebrows, enlargement of the lobes of the ear, anesthesia, rhinorrhea, crusts in the nasal vestibule, hyperpigmented and hypopigmented areas on the body, interosseous atrophy, retraction of the fourth and fifth fingers of the right hand, flattening of the thenar and hypothenar eminences, enlargement of the ulnar and greater auricular nerves, and ulcerations of the tips of the fingers. Leprosy bacilli were found on the skin in 8 of the 15 locations in which they were sought.

Treatment has consisted of 100 mg. of isoniazid (Nydrazid; isonicotinic

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