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September 1953


AMA Arch Derm Syphilol. 1953;68(3):336-337. doi:10.1001/archderm.1953.01540090098015

Ariboflavinosis is the cause of many cases of angular stomatitis, but accumulating experiences have shown that not all cases are due to a specific riboflavin deficiency. Moore, Minnich, Vilter, and Spies,1 and Ellenberg and Pollack2 have used the name pseudoariboflavinosis for such cases. In this term is included (1) angular stomatitis which may be caused by the trauma of placing poor-fitting artificial dentures or by dental malocclusions and (2) angular stomatitis caused by sensitizing and irritating substances, like tooth powders and pastes, mouth washes, and, more recently, the antibiotics, such as penicillin, chlortetracycline (aureomycin), oxytetracyclin (Terramycin), and chloramphenicol. I prefer the term angular stomatitis to designate maceration and cracking of the mouth. The term "perlèche" should be discarded, because historically it implies an impetiginous origin.3 The name "cheilitis" is also confusing and has too broad a connotation.

The treatment of pseudoariboflavinotic angular stomatitis depends on the