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Article
October 1953

NEW YORK ACADEMY OF MEDICINE, SECTION ON DERMATOLOGY AND SYPHILIS

AMA Arch Derm Syphilol. 1953;68(4):463-471. doi:10.1001/archderm.1953.01540100103015

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Abstract

Leprosy, Lepromatous Type: Response to Isoniazid Therapy. Presented by Dr. William Director and Dr. Roman Lysiak.

This patient, W. Q. C., was admitted to the hospital on July 3, 1952, because of pea-sized and smaller infiltrated nodules on the face (especially on the nose), extremities, and buttocks. The lesions started to appear on the left cheek one year (?) before admission and gradually the process spread over the other surfaces of the skin.

Treatment consisted of administration of isoniazid (Rimifon), 150 mg. daily from July 10 to Aug. 25 (in total, 7 gm. and 50 mg.) and an isopropyl derivative of isoniazid (Marsilid), 150 mg. daily from Aug. 26 to Nov. 6 (in total, 10 gm. and 650 mg.).

There has been definite improvement; numerous nodules diminished in size, and some disappeared completely.

Laboratory findings on admission were as follows: A blood cell count gave the following results: red blood

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