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February 1954


Author Affiliations


From the Department of Dermatology and the Allergy Unit, University of Illinois College of Medicine (Dr. Rostenberg), and the Department of Dermatology, Northwestern University Medical School and Cook County Hospital (Dr. Bluefarb).

AMA Arch Derm Syphilol. 1954;69(2):195-205. doi:10.1001/archderm.1954.01540140063005

THE LYMPHOBLASTOMAS comprise an intriguing group of diseases of interest to workers in many fields of medicine. A major unsolved problem concerning the group is whether the members constitute clinical, pathologic, or etiologic entities, or whether they are essentially variations on the same theme. Surely among some of them there are adequate differences to determine clinical entities, but this, of course, does not mean that they are pathologic or etiologic entities; indeed, the bulk of the evidence would appear to be that they are not.*

It occurred to us that a study of certain immunological reactions in these diseases would be of interest in at least two ways. First, from the point of view of the pathogenesis of the group, if the conditions were immunologically homogeneous, it would be some evidence for their etiologic and pathogenetic relatedness. Second, from the point of view of immunology, it is known that

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