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February 1954


AMA Arch Derm Syphilol. 1954;69(2):232-234. doi:10.1001/archderm.1954.01540140100010

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Ehlers-Danlos Syndrome Associated with Exfoliation of Palms and Soles. Presented by Dr. H. A. Haynes Jr. and Dr. William C. Marsh.

Brothers, D. C., aged 14 months, and P. C., aged 2½ years, were seen because of the chief complaint that at the age of 3 months both developed mild redness and continuing sheets of desquamation from the palms and soles. Examination revealed hypermobility of the joints, dermatochalasis, and scattered ecchymoses. The mother stated that many areas of peeling are preceded by "water blisters"; the father has never seen these.

The family history revealed that the mother is "double jointed" and that in her high school days as a cheer leader she suffered aching joints after violent exercise.

Although Ronchese has reported an epidermolysis-bullosa-like eruption of the hands and feet, no reference can be found to continued exfoliation associated with Ehlers-Danlos syndrome.


Dr. H. A. Haynes Jr.: I think

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