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March 1954


AMA Arch Derm Syphilol. 1954;69(3):382-385. doi:10.1001/archderm.1954.01540150128019

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Keratosis Follicularis. Presented by Dr. Clement Counter.

A. W. and E. W., American girls, aged 18 and 16 years respectively, stated that the present eruption had begun during early childhood. Similar cutaneous changes were and are present in other members of the family, as noted in the accompanying diagram. Aggravation was reported on exposure to the sun.

On the face, neck and extremities, as well as on the forearms and legs, typical follicular papules, forming in part confluent plaques, are present. Scattered lesions are also seen on the torso.

Microscopic examination showed the characteristic changes of Darier's disease.

Treatment has consisted of vitamin A in aqueous solution (Aquasol A), 25,000-unit capsules, twice a day, and local application of 3% salicylic acid and sulfur.


Dr. A. Fletcher Hall: I would suggest, if vitamin A therapy is given, that it be given in much larger doses. I have tried to control

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