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Article
April 1954

HEXYLCAINE IN MANAGEMENT OF PRURITIC DERMATOSESClinical Evaluation of New Local Anesthetic

AMA Arch Derm Syphilol. 1954;69(4):482-485. doi:10.1001/archderm.1954.01540160084012
Abstract

PRURITUS is undoubtedly the most frequent of all the subjective complaints of the patient who seeks dermatological consultation. The etiological factors involved in the production of discomforting pruritus are manifold.

The value of local anesthetics has been ascertained in the alleviation of the discomfort which is experienced in the pruritic dermatoses. I hereby describe my experiences with a new local anesthetic, namely, hexylcaine hydrochloride.

Hexylcaine hydrochloride is the abbreviated generic name for 1-cyclohexylamino-2-propylbenzoate. It is noted that the amino group is not in the paraposition of the benzene ring. The proprietary name for this product is Cyclaine.

Pharmacological and clinical studies were carried out by Beyer and others, Ruben and Anderson, and Orkin and Rovenstine. These investigators established its low toxicity and therapeutic index. Ruben and Anderson, and Orkin and Rovenstine found it an effective agent in spinal anesthesia and nerve block.

Chemical formula of the popular local anesthetics.

Hexylcaine has a molecular weight of 297.85

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