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May 1954

ANTIBIOTICS IN TREATMENT OF EXPERIMENTAL ERYSIPELOTHRIX RHUSIOPATHIAE INFECTION OF MICE: Use of Chlortetracycline (Aureomycin), Oxytetracycline (Terramycin), and Erythromycin (Ilotycin) with Comments on Treatment of the Infection in Human Beings

Author Affiliations


From the Research Institute for Cutaneous Diseases, now the Institute of Public Health and Preventive Medicine, Temple University, Dr. John A. Kolmer, Director.

AMA Arch Derm Syphilol. 1954;69(5):570-576. doi:10.1001/archderm.1954.01540170040006

IN PREVIOUS communications, we reported results of determinations of the therapeutic effect of sulfonamide compounds, of penicillin and streptomycin, and the combined effect of sulfanilamide and penicillin in mice inoculated with Erysipelothrix rhusiopathiae.

The present study reports results of the therapeutic effects of chlortetracycline (Aureomycin), oxytetracycline (Terramycin), and erythromycin (Ilotycin) in the treatment of experimental Ery. rhusiopathiae infections of mice.


A pure culture of Erysipelothrix rhusiopathiae maintained in lyophilic form was employed. The organism was originally obtained from swine, the site of "diamond" skin disease (a mild form of swine erysipelas). Morphology and virulence have remained unchanged. Sterile water was added to the lyophilic culture and injected intra-abdominally into white mice. The heart blood of moribund animals was cultured in heart infusion broth. It was observed that 0.2 cc. of a 1: 5,000 dilution of a 48-hour culture killed mice in four to six days. This

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