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May 1954


Author Affiliations


From the Department of Dermatology and Syphilology, New York Polyclinic Medical School and Hospital.

AMA Arch Derm Syphilol. 1954;69(5):618-619. doi:10.1001/archderm.1954.01540170088015

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It is more than two decades now, since Paul and Bunnell described the heterophile antibody reaction as a diagnostic test for infectious mononucleosis and the disease became a well-established entity. But, after an analysis of the great variety of clinical cases, it became necessary to enlarge on the old concept that infectious mononucleosis presents itself solely as the glandular, anginose, or febrile type. Nevertheless, the diagnosis continues to be based upon the well-known triad of glandular enlargement, lymphocytosis, and a positive heterophile antibody reaction; although the adenopathy may confine itself to a limited area, the blood picture may not be very outspoken, and the serology may be negative in the early phase of the sickness.

Since dermatologists and syphilologists have little opportunity to observe cases of infectious mononucleosis, dermatological literature is one of the few fields where contributions to the subject have been rather sparse. It is not

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