Since glucuronic acid has been synthesized, a renewed interest has been shown in its physiological role, particularly in its influence in the so-called collagen diseases. Peterman was the first to point out a glucuronic acid deficiency in rheumatoid arthritis, as well as good therapeutic results in this disease with the calcium, potassium, or sodium salts of glucuronic acid. He also observed favorable responses in fibrositis and in hypertrophic arthritis. Similarly, Hodas, Brandon, and Maloney stated that "glucuronic acid has a definite place in the treatment of rheumatic diseases." These authors emphasize that the results obtained with glucuronic acid are comparable with, or sometimes even better than, those obtained with the standard methods of therapy. In addition, Hodas and Laage also treated sciatica at times with dramatic results.
REISS F. GLUCURONIC ACID IN THE THERAPY OF PSORIASIS. AMA Arch Derm Syphilol. 1954;69(5):619–620. doi:10.1001/archderm.1954.01540170089016
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