The use of vitamin A in the treatment of acne vulgaris has been the object of much study,* and, while vitamin A has been given to many patients with acne over the past several years, it seems to help only a few of them. Frazier and co-workers5 have shown that, in some acne cases, lack of vitamin A causes a hyperkeratinization of the hair follicles, and an accumulation of this keratin, with the secretions of the glands, is a factor in the plugging of the pores. Upon administering vitamin A, the keratin of the hair follicles returns to normal in certain cases, with the result that the plugging of the pores is much more infrequent. Inasmuch as vitamin A helps only a few cases, however, and since vitamin C is also known to play an important part in normal keratinization, as well as in combating infections and infectious diseases,
MORRIS GE. USE OF VITAMIN C IN ACNE VULGARIS. AMA Arch Derm Syphilol. 1954;70(3):363–364. doi:10.1001/archderm.1954.01540210103019
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