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September 1954


AMA Arch Derm Syphilol. 1954;70(3):367-369. doi:10.1001/archderm.1954.01540210107023

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Reticulum Cell Sarcoma with Cryoglobulinemia. Presented by Dr. Frances Pascher.


Dr. Frances Pascher: In this 33-year-old woman the striking features were "cold urticaria" for three successive winters, followed by purpura aggravated by exposure to cold, and elicited by the application of ice packs to the skin; a purpuric eruption most marked on the legs, closely resembling the so-called "pigmented lichenoid eruptions of the lower extremities''; and the finding of cryoglobulins in the blood. The patient died 20 months after the second presentation before this Society. Hypertension, albuminuria, progressive hepatosplenomegaly, and retinitis were noted before death. The essential findings on autopsy were a reticulum-cell sarcoma of the lungs, liver, spleen, and lymph nodes, and a periarteritis nodosa of the heart, aorta, and the abdominal viscera.

Dr. Irwin R. Cohen, who has made a search of the literature, has found only one other case on record of reticulum-cell sarcoma associated with

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