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September 1954


AMA Arch Derm Syphilol. 1954;70(3):388-391. doi:10.1001/archderm.1954.01540210128027

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Dermatitis Herpetiformis Treated Successfully with Promacetin. Presented by Dr. Maurice J. Costello.

P. G., a man aged 58, has had typical dermatitis herpetiformis for 20 years. The eruption was extremely pruritic, with many exacerbations and partial remissions. On several occasions he has had mouth lesions. When I first examined him he had numerous grouped, discrete, excoriated, erythematous, matchhead- to pea-sized papules and papulovesicles. On Dec. 14, 1953, Promacetin (sodium 4,4′-diaminodiphenylsulfone-2-acetylsulfonamide) 1.0 gm., t.i.d., p.c. was administered. Even though the patient had mild toxic manifestations from the drug, such as diarrhea and head- ache, the eruption disappeared in one week under this therapy. The disease was finally controlled with 0.5 gm. t.i.d. The urine was normal, and the complete blood cell count was normal except for 46% lymphocytes.


Dr. George C. Andrews: Since Dr. Costello mentioned that type of treatment to me I have used it on several patients with

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