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October 1954

GRANULOMA ANNULARE: Response to Massive Dose Therapy of Vitamin E Combined with Pantothenic Acid Derivatives

Author Affiliations


AMA Arch Derm Syphilol. 1954;70(4):468-476. doi:10.1001/archderm.1954.01540220070008

PRELIMINARY1 and supplemental2 reports have been made on the response to, and rationalization for, the use of massive dose therapy of vitamin E combined with pantothenic acid derivatives in certain phases of lupus erythematosus — a disease in the cutaneous lesions of which "the common denominator is the connective tissue."3 The present study of results obtained in the treatment of granuloma annulare reports favorable response to similar massive dose therapy in another disease entity characterized by collagenous degeneration.

Materials used in this study* were essentially those used in the treatment of certain phases of lupus erythematosus.2 Rationalization for study of response to these agents in the treatment of granuloma annulare is as follows:

  1. The etiology of granuloma annulare is not known.† Opinion remains divided regarding the concept of a polyetiologic syndrome incriminating tuberculosis ‡ and rheumatoid arthritis,§ on the basis of histologic findings, ‖

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