The action of podophyllum resin (podophyllin) on the skin and on skin lesions such as warts and keratoses is well known and has been reported by many authors. This action is essentially a spasm of the small vessels resulting in ischemia, necrosis, and sloughing, with degeneration and the production of bizarre forms of epithelial cells.1
We wish to report two instances in which the reaction to podophyllin was most unusual.
REPORT OF CASES
Case 1.—Mrs. B. R., a patient at Oklahoma University Hospital skin clinics for many years, had multiple skin cancers and keratoses. On Aug. 5 she called attention to a lesion on the right preauricular area which she stated had been treated with radium some 15 years previously for a skin cancer. There was a depressed, smooth, telangiectic scar which was bordered by a scaling erythematous process along the upper and outer edges. This process was believed