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October 1954


Author Affiliations


From the Division of Dermatology, Department of Medicine, University of California at Los Angeles, and the Wadsworth General Hospital, Veterans Administration Center.

AMA Arch Derm Syphilol. 1954;70(4):515-516. doi:10.1001/archderm.1954.01540220117018

A recent article appearing in the Archives, July, 1953, reports the use of heparin in the treatment of psoriasis.1 This preliminary report sets forth the clinical results obtained in three patients with psoriasis treated with heparin. The author believes that heparin may prove of value in the treatment of psoriasis and urges further clinical trial of this drug. No controls were used in the reported study.

Approximately 18 months ago an investigation of the use of heparin in the treatment of psoriasis was undertaken at the Veterans Administration Hospital at Los Angeles. The rationale for the use of heparin in psoriatic patients was based upon the report of Grütz and Bürger,2 who found an increase of total fats in the serum of psoriatic patients. Heparin has been found to reduce the amount of the large molecule lipoid fractions, as measured by the Goffman3 technique, in the serum

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