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December 1954


AMA Arch Derm Syphilol. 1954;70(6):823-827. doi:10.1001/archderm.1954.01540240129019

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Necrobiosis Lipoidica. Presented by Dr. Frances Pascher and Dr. Sidney C. Clyman (by invitation).

This is a 52-year-old Norwegian woman with lesions on the legs and thighs since the age of 32. New lesions have appeared on the upper extremities since the onset. Diabetes was not present in the past, nor has it appeared in this interval of time.

During a course of quinacrine (Atabrine) therapy, some of the lesions have improved. The application of local 2.5% hydrocortisone acetate ointment for three weeks produced no clinical change. Cortisone acetate was started on May 18, 1953, 100 mg. given three times daily, 75 mg. twice, 50 mg. four times a day; then 25 mg. daily until July 30, 1953. Thyroid, 1 grain, was given daily at the same time. No change in the lesions occurred. The over-all clinical appearance is in general very little changed.

The basal metabolic rate in May,

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