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January 1955


Author Affiliations

New Orleans

AMA Arch Derm. 1955;71(1):14-18. doi:10.1001/archderm.1955.01540250016004

COSMETIC disfiguration and psychologic sequelae constitute a serious problem for the patient with vitiligo. Reported successful treatment of this condition with the psoralen derivatives has stimulated considerable interest among physicians, but the frequent occurrence of undesirable side effects from local and oral application has discouraged their use. Despite careful local application of the drug, vesiculation and edema of the involved areas often develop before pigmentation occurs, and oral ingestion also is frequently associated with nausea and other gastrointestinal disturbances. The present clinical study was undertaken in an attempt to find an effective but safe treatment for vitiligo with the psoralen derivatives without undesirable side-effects.

Psoralen derivatives are crystalline principles extracted from the Ammi majus Linn. fruits, found so abundantly in the Nile Delta. Since the 13th century Egyptians have used a powder prepared from the fruit of this plant for treatment of vitiligo. The crude