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January 1955


Author Affiliations

New York

From the Vanderbilt Clinic and College of Physicians and Surgeons, Columbia Presbyterian Medical Center.

AMA Arch Derm. 1955;71(1):52-55. doi:10.1001/archderm.1955.01540250054010

IN 1953 Rothman1 reported the disappearance of onychomycosis due to T. rubrum in three of nine patients after prolonged treatment with lithium bromide, a solution of glucose and Asterol (2-dimethylamino-6-[β-diethylaminoethoxy] -benzothiazole) dihydrochloride, and a nail lacquer containing lithium bromide and Asterol base.*

A review of our records of patients with T. rubrum infections brought out a striking similarity of infection and the singular lack of response to a score of fungicides.

Between October, 1952, and June, 1953, therefore, 32 patients were instructed in the Rothman method of treatment and 21 patients were continued on a variety of other fungicidal agents.

In the former group, to be discussed in some detail, there were 10 males and 22 females, ranging in age from 9 to 68 years. With the exception of one girl, whose history will be given below, all patients were 23 years or older. Thirty subjects