IN 1953 Rothman1 reported the disappearance of onychomycosis due to T. rubrum in three of nine patients after prolonged treatment with lithium bromide, a solution of glucose and Asterol (2-dimethylamino-6-[β-diethylaminoethoxy] -benzothiazole) dihydrochloride, and a nail lacquer containing lithium bromide and Asterol base.*
A review of our records of patients with T. rubrum infections brought out a striking similarity of infection and the singular lack of response to a score of fungicides.
Between October, 1952, and June, 1953, therefore, 32 patients were instructed in the Rothman method of treatment and 21 patients were continued on a variety of other fungicidal agents.
In the former group, to be discussed in some detail, there were 10 males and 22 females, ranging in age from 9 to 68 years. With the exception of one girl, whose history will be given below, all patients were 23 years or older. Thirty subjects
KESTEN BM, BENHAM R, SILVA M. TREATMENT OF ONYCHOMYCOSIS DUE TO TRICHOPHYTON RUBRUM. AMA Arch Derm Syphilol. 1955;71(1):52–55. doi:10.1001/archderm.1955.01540250054010
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