The following clinical study was done to compare the effects of hydrocortisone free alcohol and hydrocortisone acetate as topical medicaments and to evaluate the most practical concentration for topical therapy. Although cortisone differs from hydrocortisone in only structural details—there is a ketone group at the C-11 position in the steroid nucleus in place of a hydroxyl radical—cortisone has been found to be rather ineffective topically1 in suppressing inflammatory reaction in the skin. On the other hand, hydrocortisone, which is believed to be the principal hormone secreted by the adrenal cortex,2 is effective.3 The superior effect of hydrocortisone
FRANK L, STRITZLER C, KAUFMAN J. HYDROCORTISONE (COMPOUND F) FREE ALCOHOL AND HYDROCORTISONE ACETATE FOR TOPICAL USE: A Clinical Evaluation. AMA Arch Derm Syphilol. 1955;71(1):117–120. doi:10.1001/archderm.1955.01540250119024
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