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February 1955

IDIOPATHIC HYPERLIPEMIA AND PRIMARY HYPERCHOLESTEREMIC XANTHOMATOSIS: V. Analysis of Serum Lipoproteins by Means of Ultracentrifuge Before and After Administration of Heparin

Author Affiliations


From the Department of Dermatology, Harvard Medical School, and the Dermatologic Service, Massachusetts General Hospital.

AMA Arch Derm. 1955;71(2):158-171. doi:10.1001/archderm.1955.01540260016005

IN A PREVIOUS communication of this series1 it had been reported that a single intravenous injection of 50 mg. of heparin consistently caused a slight decrease in serum cholesterol in primary hypercholesteremic xanthomatosis, and a slight decrease also in phospholipids, neutral fat, and turbidity in idiopathic hyperlipemia. Subsequently it was observed2 that the prolonged administration of heparin caused a considerable decrease in turbidity and in all the lipid values in idiopathic hyperlipemia.

In order to obtain information about the action of heparin on the serum lipoproteins, ultracentrifugal analyses of the lipoproteins were carried out before and after a single intravenous injection of 100 mg. of heparin in normal persons as well as in patients with primary hypercholesteremic xanthomatosis and idiopathic hyperlipemia. In addition, similar studies were carried out in several patients with idiopathic hyperlipemia before and during the prolonged administration of heparin.


Blood was collected as

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