HAHN IN 19431 showed that heparin injected into an animal could clarify the turbidity of alimentary lipemia, but he could not demonstrate the same phenomenon when he added heparin directly to such plasma in vitro. Later Anderson2 successfully produced the "clearing" effect outside the body by treating lipemic plasma with plasma taken from another animal shortly after injecting the latter intravenously with heparin. These results seemed to show that heparin can incite the elaboration in plasma of an agent capable of modifying lipoprotein particles.
Graham and co-workers3 advanced these studies on the role of heparin in mediating the transport and transformation of lipoidsby showing they could alter the distribution of the various kinds of lipoproteins and partly prevent the formation of the kind that is associated with and supposedly responsible for producing atheromata during cholesterol feeding. They found in humans suffering with