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Article
February 1955

ALLERGIC CONTACT DERMATITIS DUE TO HISTAMINE-RELEASING DRUG 48-80

Author Affiliations

Philadelphia

From the Departments of Physiology and Dermatology, School of Medicine, and Department of Dermatology, Graduate School of Medicine, University of Pennsylvania.

AMA Arch Derm. 1955;71(2):190-191. doi:10.1001/archderm.1955.01540260048010
Abstract

A WIDE variety of chemicals are now known to be capable of releasing histamine from the skin without producing any evidence of cell damage. These agents include morphine, codeine, 5-hydroxytryptamine (Serotonin), stilbamidine, and most potent of all, 48-80.1 A single molecule of this last compound has the astounding property of being able to liberate 30 molecules of histamine. Chemically, 48-80 is a complex amine, a condensation product of p-methoxyphenylethyl-methylamine and formaldehyde. It is probably a mixture of the dimer, trimer, and tetramer: When given intradermally in man it produces the typical response seen after histamine injection: wheal, flare, and a mixture of pruritus and pain.

During the course of experimental studies on the effect of 48-80* on man,2 an allergic state developed in one of the subjects. This is reported here because of the unique nature of the pharmacologic

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