A WIDE variety of chemicals are now known to be capable of releasing histamine from the skin without producing any evidence of cell damage. These agents include morphine, codeine, 5-hydroxytryptamine (Serotonin), stilbamidine, and most potent of all, 48-80.1 A single molecule of this last compound has the astounding property of being able to liberate 30 molecules of histamine. Chemically, 48-80 is a complex amine, a condensation product of p-methoxyphenylethyl-methylamine and formaldehyde. It is probably a mixture of the dimer, trimer, and tetramer: When given intradermally in man it produces the typical response seen after histamine injection: wheal, flare, and a mixture of pruritus and pain.
During the course of experimental studies on the effect of 48-80* on man,2 an allergic state developed in one of the subjects. This is reported here because of the unique nature of the pharmacologic
BENJAMIN FB, BEERMAN H, SHELLEY WB. ALLERGIC CONTACT DERMATITIS DUE TO HISTAMINE-RELEASING DRUG 48-80. AMA Arch Derm. 1955;71(2):190–191. doi:10.1001/archderm.1955.01540260048010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: