There is no other field of dermatopathology that has been neglected as much as that of the neuropathology of the skin. Among all the precise descriptions of changes in epidermal cells, connective tissue, and ground substance, one seldom finds an elaboration of the changes in the nerve patterns. Pautrier's discussion of this discrepancy is still as pertinent as it was when it was published in 1935.1 One of the chief reasons for the lack of interest in this subject is the fact that very little has been done to delineate the sensory bodies that are found in normal skin, and how these endings may vary from location to location. Studies have been made of special areas and with techniques which are difficult to use, but on a practical level there are few undisputed facts known which the dermatologist interested in nerve tissue can verify
WINKELMANN RK. Some Sensory Nerve Endings in the SkinPreliminary Report on the Morphology of Cutaneous Sensation. AMA Arch Derm. 1955;71(3):373–378. doi:10.1001/archderm.1955.01540270085012
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